Hydrogen chloride-ethyl acetate → HCID 22175486, compound

Participants

Reaction Steps

To a solution of tert-butyl[6-(cyanomethyl)-2-isobutyl-1-oxo-4-phenyl-1,2-dihydro-3-isoquinolinyl]methylcarbamate (0.13 g, 0.29 mmol) in ethyl acetate (4 mL) was added a 4N hydrogen chloride ethyl acetate solution (1 mL), and the mixture was stirred at room temperature for 12 h. The reaction was concentrated under reduced pressure, and the residue was crystallized from diisopropyl ether and washed with diisopropyl ether (5 mL×2) to give [3-(aminomethyl)-2-isobutyl-1-oxo-4-phenyl-1,2-dihydro-6-isoquinolinyl]acetonitrile hydrochloride (0.096 g, 88%) as a pale yellow powder.

Provenance & Evidence