Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Bicyclo(2.2.1)hept-5-ene-2-methanol | HCID 78946 | — |
| Reactant | 3-(4-Fluorophenyl)-2-propenoic acid | HCID 98070 | — |
| Catalyst | HCID 86657292 | HCID 86657292 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 86657291 | HCID 86657291 | 68% |
Reaction Steps
10 g (60 mmol) of 4-fluoro-cinnamic acid, 7.45 g (60 mmol) of 5-norbornene-2-methanol, and 0.3 g (0.02 eq.) of zirconium(IV) acetate hydroxide were added to 50 ml of toluene and stirred. The mixture was heated to 145° C. under N2 atmosphere and azeotropically refluxed for 24 hours. After the reaction, the mixture cooled down to room temperature and was added with 100 volume % of ethyl acetate. The resulting product was extracted with 1M HCl and washed again with water. The organic layer was dried with Na2SO4 and the solvent was evaporated out to give a highly viscous material. (Yield: 68%, Purity (GC): 92%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08343597B2 |
|---|
| Source dataset | uspto-grants-2013_01 |
|---|
| ORD ID | ord-4417e4d179f44196bb9f2cbae47cac32 |
|---|
| Source note | uspto-grants-2013_01 |
|---|
