HCID 131726789, compound → HCID 131726790, compound

HRID 1797845Notes

Reaction equation

[NH:1]([C:35]([O:37]C(C)(C)C)=O)[C@H:2]([C:12]([NH:14][C@H:15]([C:25]([O:27]N1C(=O)CCC1=O)=[O:26])[CH2:16][CH2:17][C:18](=[O:24])[O:19]C(C)(C)C)=[O:13])[CH2:3][CH2:4][C:5](=[O:11])[O:6]C(C)(C)C.[NH2:42][C@H:43](C(O)=O)[CH2:44][CH2:45][C:46](=[O:48])[OH:47].[CH3:52][N:53]1[C@@H:70]2[CH2:71][C:58]3[CH:59]=[CH:60][C:61]([O:72][CH3:73])=[C:62]4[O:63][C@H:64]5[C:65]([CH2:67][CH2:68][C@@H:69]2[C@:56]5([C:57]=34)[CH2:55][CH2:54]1)=[O:66]>>[NH2:42][C@H:43]([C:35]([NH:1][C@H:2]([C:12]([NH:14][C@H:15]([C:25]([OH:27])=[O:26])[CH2:16][CH2:17][C:18](=[O:24])[OH:19])=[O:13])[CH2:3][CH2:4][C:5](=[O:11])[OH:6])=[O:37])[CH2:44][CH2:45][C:46](=[O:47])[OH:48].[CH3:52][N:53]1[C@@H:70]2[CH2:71][C:58]3[CH:59]=[CH:60][C:61]([O:72][CH3:73])=[C:62]4[O:63][C@H:64]5[C:65]([CH2:67][CH2:68][C@@H:69]2[C@:56]5([C:57]=34)[CH2:55][CH2:54]1)=[O:66]

Participants

Reactant 2

HCID 131726789HCID 131726789, compound

HCID 131726791HCID 131726791, compound

Product 1

HCID 131726790HCID 131726790, compound

Procedure

Glu-Glu-Glu-Hydrocodone was prepared by a similar method to Example 41 except the amino acid starting material was Boc-Glu(OtBu)-Glu(OtBu)-OSu and the conjugate starting material was Glu-Hydrocodone.

Sources & evidence

ORD record: ord-3e9d44068e134777a024fb5e1d44a96d
Source dataset: uspto-grants-2013_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08343927B2

Reaction notes

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