HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1797890Generated: November 4, 2026
2-Phenylaminomethylene-malonic acid diethyl ester → HCID 178469510, compound
https://huagongshe.com/reaction/1797890
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Phenylaminomethylene-malonic acid diethyl ester | HCID 264327 | — |
| Solvent | 1,1'-Biphenyl, mixt. with 1,1'-oxybis(benzene) | HCID 24670 | — |
| Product | HCID 178469510 | HCID 178469510 | — |
Reaction Steps
The 2-phenylaminomethylene-malonic acid diethyl ester was refluxed in Dowtherm® for 15 min to 2 h. The reaction mixture was cooled to 80° C. and solid was collected by filtration and washed with hexane to yield crude ethyl 4-hydroxy-quinoline-3-carboxylate 2a which was used in next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08343957B2 |
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| Source dataset | uspto-grants-2013_01 |
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| ORD ID | ord-e8a896e1a96e47dbba45ae0d801fe82a |
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| Source note | uspto-grants-2013_01 |
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