4-Fluoroaniline → HCID 178469553, compound

HRID 1797895Notes

Reaction equation

[OH:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[CH:4][C:3]=1[C:12]([O:14][CH2:15][CH3:16])=[O:13].[F:17]C1C=CC(N)=CC=1>>[F:17][C:9]1[CH:10]=[C:11]2[C:6](=[CH:7][CH:8]=1)[N:5]=[CH:4][C:3]([C:12]([O:14][CH2:15][CH3:16])=[O:13])=[C:2]2[OH:1]

Participants

Reactant 2

HCID 97314-Fluoroaniline

HCID 178469510HCID 178469510, compound

Product 1

HCID 178469553HCID 178469553, compound

Procedure

The title compound was prepared following the procedure described in Step 1 for the synthesis of 2a using 4-fluoroaniline instead of aniline. 1H NMR (DMSO-d6) δ (ppm): 1.15 (3H, t, J=7.080 Hz), 4.1 (2H, q, J=7.08 Hz), 7.61 (1H, dd, J=8.30, 2.93 Hz), 7.68 (1H, dd, J=9.03, 4.63 Hz), 7.80 (1H, dd, J=9.27, 2.93 Hz), 8.56 (1H, s). m/z 236.5 (MH+).

Sources & evidence

ORD record: ord-fb2bf6cc3ea545d59741852b2aaaddb0
Source dataset: uspto-grants-2013_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08343957B2

Reaction notes

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