1-Butylpiperazine → 4-(3-(3-((4-butylpiperazin-1-yl)(imino)methyl)phenyl)ureido)-N-methylbenzene sulfonamide

HRID 1797937Notes

Reaction equation

HRID 1797937 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]([NH:9][C:10](=[O:23])[NH:11][C:12]2[CH:17]=[CH:16][C:15]([S:18]([NH:21][CH3:22])(=[O:20])=[O:19])=[CH:14][CH:13]=2)[CH:6]=[CH:7][CH:8]=1)#[N:2].[CH2:24]([N:28]1[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]1)[CH2:25][CH2:26][CH3:27]>>[CH2:24]([N:28]1[CH2:33][CH2:32][N:31]([C:1](=[NH:2])[C:3]2[CH:4]=[C:5]([NH:9][C:10](=[O:23])[NH:11][C:12]3[CH:17]=[CH:16][C:15]([S:18]([NH:21][CH3:22])(=[O:19])=[O:20])=[CH:14][CH:13]=3)[CH:6]=[CH:7][CH:8]=2)[CH2:30][CH2:29]1)[CH2:25][CH2:26][CH3:27]

Participants

3

Reactant 2

HCID 4243221-ButylpiperazineHCID 575040374-(3-(3-cyanophenyl)ureido)-N-methylbenzenesulfonamide

Product 1

HCID 468519844-(3-(3-((4-butylpiperazin-1-yl)(imino)methyl)phenyl)ureido)-N-methylbenzene sulfonamideYield 1%

Procedure

The title compound was prepared from 4-(3-(3-cyanophenyl)ureido)-N-methylbenzenesulfonamide following procedure C and using 2.2 equivalents of n-butylpiperazine as secondary amine. The product was purified by preparative HPLC.

Workup

  1. customThe product was purified by preparative HPLC

Sources & evidence

ORD record
ord-12a6656759df48ee84c951bda6a7a682
Source dataset
uspto-grants-2013_01
Patent number
US08343963B2

Reaction notes

Loading…