1-Butylpiperazine → HCID 46851985, compound

HRID 1797938Notes

Reaction equation

HRID 1797938 reaction equation
[CH2:1]([NH:4][S:5]([C:8]1[CH:13]=[CH:12][C:11]([NH:14][C:15](=[O:26])[NH:16][C:17]2[CH:18]=[C:19]([CH:23]=[CH:24][CH:25]=2)[C:20](=[NH:22])[NH2:21])=[CH:10][CH:9]=1)(=[O:7])=[O:6])[CH2:2][CH3:3].[CH2:27]([N:31]1[CH2:36][CH2:35]N[CH2:33][CH2:32]1)[CH2:28][CH2:29][CH3:30]>>[CH2:27]([N:31]1[CH2:36][CH2:35][N:22]([C:20](=[NH:21])[C:19]2[CH:18]=[C:17]([NH:16][C:15](=[O:26])[NH:14][C:11]3[CH:10]=[CH:9][C:8]([S:5]([NH:4][CH2:1][CH2:2][CH3:3])(=[O:6])=[O:7])=[CH:13][CH:12]=3)[CH:25]=[CH:24][CH:23]=2)[CH2:33][CH2:32]1)[CH2:28][CH2:29][CH3:30]

Participants

3

Reactant 2

HCID 4243221-ButylpiperazineHCID 57496176HCID 57496176, compound

Product 1

HCID 46851985HCID 46851985, compoundYield 13%

Procedure

The title compound was prepared from 3-(3-(4-(N-propylsulfamoyl)phenyl)ureido)benzimidamide following procedure C and using 2 equivalents of n-butylpiperazine as secondary amine. The product was purified by preparative HPLC.

Workup

  1. customThe product was purified by preparative HPLC

Sources & evidence

ORD record
ord-b7694d33e8b34be694cf55085afc43b7
Source dataset
uspto-grants-2013_01
Patent number
US08343963B2

Reaction notes

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