1-Butylpiperazine → HCID 57504034, compound

HRID 1797940Notes

Reaction equation

HRID 1797940 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]([NH:9][C:10]([NH:12][C:13]2[CH:18]=[CH:17][C:16]([S:19]([N:22]3[CH2:27][CH2:26][O:25][CH2:24][CH2:23]3)(=[O:21])=[O:20])=[CH:15][CH:14]=2)=[O:11])[CH:6]=[CH:7][CH:8]=1)#[N:2].[CH2:28]([N:32]1[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]1)[CH2:29][CH2:30][CH3:31]>>[CH2:28]([N:32]1[CH2:37][CH2:36][N:35]([C:1](=[NH:2])[C:3]2[CH:4]=[C:5]([NH:9][C:10]([NH:12][C:13]3[CH:14]=[CH:15][C:16]([S:19]([N:22]4[CH2:27][CH2:26][O:25][CH2:24][CH2:23]4)(=[O:21])=[O:20])=[CH:17][CH:18]=3)=[O:11])[CH:6]=[CH:7][CH:8]=2)[CH2:34][CH2:33]1)[CH2:29][CH2:30][CH3:31]

Participants

3

Reactant 2

HCID 4243221-ButylpiperazineHCID 67523979HCID 67523979, compound

Product 1

HCID 57504034HCID 57504034, compoundYield 72%

Procedure

The title compound was prepared from 1-(3-cyanophenyl)-3-(4-(morpholinosulfonyl)phenyl)urea following procedure C and using 2 equivalents of n-butylpiperazine as secondary amine. The product was purified by preparative HPLC.

Workup

  1. customThe product was purified by preparative HPLC

Sources & evidence

ORD record
ord-c7af9fc59aaf4338aea36f1b2ec665bb
Source dataset
uspto-grants-2013_01
Patent number
US08343963B2

Reaction notes

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