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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1797942Generated: November 3, 2026

1-Butylpiperazine → 4-(3-(3-((4-butylpiperazin-1-yl)(imino)methyl)phenyl)ureido)-N-(4-sulfamoylphenyl)benzenesulfonamide

https://huagongshe.com/reaction/1797942

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-ButylpiperazineHCID 424322—
Reactant4-(3-(3-cyanophenyl)ureido)-N-(4-sulfamoylphenyl)benzenesulfonamideHCID 57496178—
Product4-(3-(3-((4-butylpiperazin-1-yl)(imino)methyl)phenyl)ureido)-N-(4-sulfamoylphenyl)benzenesulfonamideHCID 5749613916.5%

Reaction Steps

The title compound was prepared from 4-(3-(3-cyanophenyl)ureido)-N-(4-sulfamoylphenyl)benzenesulfonamide following procedure C and using 1.2 equivalents of n-butylpiperazine as secondary amine. The product was purified by preparative HPLC.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08343963B2
Source datasetuspto-grants-2013_01
ORD IDord-71e40960a7104644814ec9ed7bf7caae
Source noteuspto-grants-2013_01