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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1797943Generated: November 3, 2026

Diisopropylethylamine → methyl 4-(imino(3-(3-(4-(N-(4-sulfamoylphenyl)sulfamoyl)phenyl)ureido)phenyl)methyl)piperazine-1-carboxylate

https://huagongshe.com/reaction/1797943

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDiisopropylethylamineHCID 81531—
ReactantMethyl piperazine-1-carboxylateHCID 142729—
Reactant4-(3-(3-cyanophenyl)ureido)-N-(4-sulfamoylphenyl)benzenesulfonamideHCID 57496178—
Productmethyl 4-(imino(3-(3-(4-(N-(4-sulfamoylphenyl)sulfamoyl)phenyl)ureido)phenyl)methyl)piperazine-1-carboxylateHCID 574961405.3%

Reaction Steps

The title compound was prepared from 4-(3-(3-cyanophenyl)ureido)-N-(4-sulfamoylphenyl)benzenesulfonamide following procedure C and using 1 equivalent of methyl piperazine-1-carboxylate as secondary amine and 1 equivalent of DIEA as base. The product was purified by preparative HPLC.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08343963B2
Source datasetuspto-grants-2013_01
ORD IDord-1248aa808c254e1b9b050c5a86524b06
Source noteuspto-grants-2013_01