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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1797945Generated: November 1, 2026

1-Methylpiperazine → 4-(3-(3-(imino(4-methylpiperazin-1-yl)methyl)phenyl)ureido)-N-(4-sulfamoylphenyl)benzenesulfonamide

https://huagongshe.com/reaction/1797945

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-MethylpiperazineHCID 53167—
ReactantDiisopropylethylamineHCID 81531—
Reactant4-(3-(3-cyanophenyl)ureido)-N-(4-sulfamoylphenyl)benzenesulfonamideHCID 57496178—
Product4-(3-(3-(imino(4-methylpiperazin-1-yl)methyl)phenyl)ureido)-N-(4-sulfamoylphenyl)benzenesulfonamideHCID 5749614133.8%

Reaction Steps

The title compound was prepared from 4-(3-(3-cyanophenyl)ureido)-N-(4-sulfamoylphenyl)benzenesulfonamide following procedure C and using 1 equivalent of 1-methylpiperazine as secondary amine and 1 equivalent of DIEA as base. The product was purified by preparative HPLC.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08343963B2
Source datasetuspto-grants-2013_01
ORD IDord-69ce379188054608a4393427423d20d9
Source noteuspto-grants-2013_01