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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1797947Generated: November 2, 2026

1-(2-Hydroxyethyl)piperazine → 4-(3-(3-((4-(2-hydroxyethyl)piperazin-1-yl)(imino)methyl)phenyl)ureido)-N-(4-sulfamoylbenzyl)benzenesulfonamide

https://huagongshe.com/reaction/1797947

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(2-Hydroxyethyl)piperazineHCID 7677—
Reactant4-(3-(3-cyanophenyl)ureido)-N-(4-sulfamoylbenzyl)benzenesulfonamideHCID 57496180—
Product4-(3-(3-((4-(2-hydroxyethyl)piperazin-1-yl)(imino)methyl)phenyl)ureido)-N-(4-sulfamoylbenzyl)benzenesulfonamideHCID 574961422%

Reaction Steps

The title compound was prepared from 4-(3-(3-cyanophenyl)ureido)-N-(4-sulfamoylbenzyl)benzenesulfonamide following procedure C and using 1.2 equivalent of 2-(piperazin-1-yl)ethanol as secondary amine. The product was purified by preparative TLC (eluent: petrolether/DCM/MeOH 2:3:1 containing 2% of a 7 M NH3 solution in MeOH).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08343963B2
Source datasetuspto-grants-2013_01
ORD IDord-f9d59bd589ac462cb14d395f49fbe5d7
Source noteuspto-grants-2013_01