1-Butylpiperazine → HCID 46852142, compound

HRID 1797960Notes

Reaction equation

[C:1]([C:3]1[CH:4]=[C:5]([NH:9][C:10](=[O:34])[NH:11][C:12]2[CH:17]=[CH:16][C:15]([S:18]([N:21]3[CH2:29][C:28]4[C:23](=[CH:24][CH:25]=[C:26]([S:30]([NH2:33])(=[O:32])=[O:31])[CH:27]=4)[CH2:22]3)(=[O:20])=[O:19])=[CH:14][CH:13]=2)[CH:6]=[CH:7][CH:8]=1)#[N:2].[CH2:35]([N:39]1[CH2:44][CH2:43][NH:42][CH2:41][CH2:40]1)[CH2:36][CH2:37][CH3:38]>>[CH2:35]([N:39]1[CH2:44][CH2:43][N:42]([C:1](=[NH:2])[C:3]2[CH:4]=[C:5]([NH:9][C:10](=[O:34])[NH:11][C:12]3[CH:17]=[CH:16][C:15]([S:18]([N:21]4[CH2:29][C:28]5[C:23](=[CH:24][CH:25]=[C:26]([S:30]([NH2:33])(=[O:32])=[O:31])[CH:27]=5)[CH2:22]4)(=[O:20])=[O:19])=[CH:14][CH:13]=3)[CH:6]=[CH:7][CH:8]=2)[CH2:41][CH2:40]1)[CH2:36][CH2:37][CH3:38]

Participants

Reactant 2

HCID 4243221-Butylpiperazine

HCID 57496182HCID 57496182, compound

Product 1

HCID 46852142HCID 46852142, compoundYield 12%

Procedure

The title compound was prepared from 2-(4-(3-(3-cyanophenyl)ureido)phenylsulfonyl)isoindoline-5-sulfonamide following procedure C and using 3 equivalents of n-butylpiperazine as secondary amine. The product was purified by preparative HPLC.

Workup

customThe product was purified by preparative HPLC

Sources & evidence

ORD record: ord-869c8b4d9bd9425dbbbdb36c033da094
Source dataset: uspto-grants-2013_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08343963B2

Reaction notes

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