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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1797980Generated: October 26, 2026

1-(Cyclopropylmethyl)piperazine → 4-(3-(3-((4-(cyclopropylmethyl)piperazin-1-yl)(imino)methyl)phenyl)ureido)-N-(4-sulfamoylbenzyl)benzenesulfonamide

https://huagongshe.com/reaction/1797980

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(Cyclopropylmethyl)piperazineHCID 965875—
Reactant4-(3-(3-cyanophenyl)ureido)-N-(4-sulfamoylbenzyl)benzenesulfonamideHCID 57496180—
Product4-(3-(3-((4-(cyclopropylmethyl)piperazin-1-yl)(imino)methyl)phenyl)ureido)-N-(4-sulfamoylbenzyl)benzenesulfonamideHCID 5749616757%

Reaction Steps

The title compound was prepared from 4-(3-(3-cyanophenyl)ureido)-N-(4-sulfamoylbenzyl)benzenesulfonamide following procedure C and using 2.2 equivalent of 1-(cyclopropylmethyl)piperazine as secondary amine. The product was purified by preparative HPLC.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08343963B2
Source datasetuspto-grants-2013_01
ORD IDord-b6ca31e5cd6c4845b1352b94edd1316c
Source noteuspto-grants-2013_01