Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1797982Generated: October 27, 2026

1-(Tetrahydro-2-furylmethyl)piperazine → 4-(3-(3-(imino(4-((tetrahydrofuran-2-yl)methyl)piperazin-1-yl)methyl)phenyl)ureido)-N-(4-sulfamoylbenzyl)benzenesulfonamide

https://huagongshe.com/reaction/1797982

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(Tetrahydro-2-furylmethyl)piperazineHCID 2737265—
Reactant4-(3-(3-cyanophenyl)ureido)-N-(4-sulfamoylbenzyl)benzenesulfonamideHCID 57496180—
Product4-(3-(3-(imino(4-((tetrahydrofuran-2-yl)methyl)piperazin-1-yl)methyl)phenyl)ureido)-N-(4-sulfamoylbenzyl)benzenesulfonamideHCID 5749616948%

Reaction Steps

The title compound was prepared from 4-(3-(3-cyanophenyl)ureido)-N-(4-sulfamoylbenzyl)benzenesulfonamide following procedure C and using 2.2 equivalent of 1-(tetrahydro-2-furylmethyl)piperazine as secondary amine. The product was purified by preparative HPLC.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08343963B2
Source datasetuspto-grants-2013_01
ORD IDord-ea5d7e2a91a8407c8ccce686a646fee9
Source noteuspto-grants-2013_01