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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1797983Generated: November 1, 2026

1-(2-Methoxyethyl)piperazine → 4-(3-(3-(imino(4-(2-methoxyethyl)piperazin-1-yl)methyl)phenyl)ureido)-N-(4-sulfamoylbenzyl)benzenesulfonamide

https://huagongshe.com/reaction/1797983

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(2-Methoxyethyl)piperazineHCID 2734638—
Reactant4-(3-(3-cyanophenyl)ureido)-N-(4-sulfamoylbenzyl)benzenesulfonamideHCID 57496180—
Product4-(3-(3-(imino(4-(2-methoxyethyl)piperazin-1-yl)methyl)phenyl)ureido)-N-(4-sulfamoylbenzyl)benzenesulfonamideHCID 5749617041.5%

Reaction Steps

The title compound was prepared from 4-(3-(3-cyanophenyl)ureido)-N-(4-sulfamoylbenzyl)benzenesulfonamide following procedure C and using 2.2 equivalent of 1-(2-methoxyethyl)piperazine as secondary amine. The product was purified by preparative HPLC.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08343963B2
Source datasetuspto-grants-2013_01
ORD IDord-8b3c57b4bc554e72862e9af4261f0a54
Source noteuspto-grants-2013_01