1-Butylpiperazine → HCID 57496171, compound

HRID 1797984Notes

Reaction equation

[C:1]([C:3]1[CH:4]=[C:5]([NH:9][C:10](=[O:32])[NH:11][C:12]2[CH:17]=[CH:16][C:15]([S:18]([NH:21][CH2:22][C:23]3[S:27][C:26]([S:28]([NH2:31])(=[O:30])=[O:29])=[CH:25][CH:24]=3)(=[O:20])=[O:19])=[CH:14][CH:13]=2)[CH:6]=[CH:7][CH:8]=1)#[N:2].[CH2:33]([N:37]1[CH2:42][CH2:41][NH:40][CH2:39][CH2:38]1)[CH2:34][CH2:35][CH3:36]>>[CH2:33]([N:37]1[CH2:42][CH2:41][N:40]([C:1](=[NH:2])[C:3]2[CH:4]=[C:5]([NH:9][C:10](=[O:32])[NH:11][C:12]3[CH:17]=[CH:16][C:15]([S:18]([NH:21][CH2:22][C:23]4[S:27][C:26]([S:28]([NH2:31])(=[O:30])=[O:29])=[CH:25][CH:24]=4)(=[O:20])=[O:19])=[CH:14][CH:13]=3)[CH:6]=[CH:7][CH:8]=2)[CH2:39][CH2:38]1)[CH2:34][CH2:35][CH3:36]

Participants

Reactant 2

HCID 4243221-Butylpiperazine

HCID 67523746HCID 67523746, compound

Product 1

HCID 57496171HCID 57496171, compoundYield 58%

Procedure

The title compound was prepared from 5-((4-(3-(3-cyanophenyl)ureido) phenylsulfonamido)methyl)thiophene-2-sulfonamide following procedure C and using 2.2 equivalent of n-butylpiperazine as secondary amine. The product was purified by preparative HPLC.

Workup

customThe product was purified by preparative HPLC

Sources & evidence

ORD record: ord-05120d0d2e8947baab988744a7cef35a
Source dataset: uspto-grants-2013_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08343963B2

Reaction notes

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