1-Butylpiperazine → HCID 57496172, compound

HRID 1797985Notes

Reaction equation

[C:1]([C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10](=[O:33])[NH:11][C:12]2[CH:17]=[CH:16][C:15]([S:18]([NH:21][CH2:22][C:23]3[CH:28]=[CH:27][C:26]([S:29](=[O:32])(=[O:31])[NH2:30])=[CH:25][CH:24]=3)(=[O:20])=[O:19])=[CH:14][CH:13]=2)=[CH:5][CH:4]=1)#[N:2].[CH2:34]([N:38]1[CH2:43][CH2:42][NH:41][CH2:40][CH2:39]1)[CH2:35][CH2:36][CH3:37]>>[CH2:34]([N:38]1[CH2:43][CH2:42][N:41]([C:1](=[NH:2])[C:3]2[CH:4]=[CH:5][C:6]([NH:9][C:10](=[O:33])[NH:11][C:12]3[CH:13]=[CH:14][C:15]([S:18]([NH:21][CH2:22][C:23]4[CH:28]=[CH:27][C:26]([S:29](=[O:31])(=[O:32])[NH2:30])=[CH:25][CH:24]=4)(=[O:20])=[O:19])=[CH:16][CH:17]=3)=[CH:7][CH:8]=2)[CH2:40][CH2:39]1)[CH2:35][CH2:36][CH3:37]

Participants

Reactant 2

HCID 4243221-Butylpiperazine

HCID 57496184HCID 57496184, compound

Product 1

HCID 57496172HCID 57496172, compoundYield 2.4%

Procedure

The title compound was prepared from 4-(3-(4-cyanophenyl)ureido)-N-(4-sulfamoylbenzyl)benzenesulfonamide following procedure C and using 3 equivalents of n-butylpiperazine as secondary amine. The product was purified by preparative HPLC.

Workup

customThe product was purified by preparative HPLC

Sources & evidence

ORD record: ord-95fb7adbdea14834a89f4f8bb213aad5
Source dataset: uspto-grants-2013_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08343963B2

Reaction notes

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