HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1797986Generated: November 2, 2026
Water → methyl 4-((acetylimino)(3-(3-(4-(N-(4-sulfamoylbenzyl)sulfamoyl)phenyl)ureido)phenyl)methyl)piperazine-1-carboxylate
https://huagongshe.com/reaction/1797986
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Acetyl chloride | HCID 6367 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | HCID 57496162 | HCID 57496162 | — |
| Solvent | dichloromethane N,N-dimethylformamide | HCID 22350042 | — |
| Product | methyl 4-((acetylimino)(3-(3-(4-(N-(4-sulfamoylbenzyl)sulfamoyl)phenyl)ureido)phenyl)methyl)piperazine-1-carboxylate | HCID 46852302 | 19% |
Reaction Steps
100 mg of compound 60 were dissolved in 2 ml of DCM/DMF 1:1 solution, containing 2 eq of DIEA. Under stirring and at 0° C., 6 eq of acetylchloride were added portionwise during 30 minutes. The solution was stirred overnight at rt, then water was added and a precipitate formed. The precipitate was separated and the title compound was obtained after preparative HPLC purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08343963B2 |
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| Source dataset | uspto-grants-2013_01 |
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| ORD ID | ord-8bfd9bf696644d6898cdbc850aa1deaf |
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| Source note | uspto-grants-2013_01 |
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