HuagongsheHuagongshe Chemistry Print Report · For research reference only
Indole → 1-(Phenylsulfonyl)-1H-indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Indole | HCID 798 | — |
| Reactant | Benzenesulfonyl chloride | HCID 7369 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Catalyst | Tetrabutylammonium hydrogen sulfate | HCID 94433 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-(Phenylsulfonyl)-1H-indole | HCID 315017 | 89% |
Reaction Steps
1-(phenylsulphonyl)indole is prepared according to the procedures described in S. Roy, G. W. Gribble Tetrahedron Lett. 2005, 46, 1325-1328, by reaction of indole with phenylsulphonyl chloride (PhSO2C1) in a basic medium (NaOH) in the presence of a catalytic quantity of (n-Bu)4NHSO4 in CH2Cl2 at 0° C. for 1 hour then at ambient temperature for 4 hours (yield: 89%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08343964B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-400a3cbe7a8a4401b87b716ba19f9a70 |
| Source note | uspto-grants-2013_01 |