HuagongsheHuagongshe Chemistry Print Report · For research reference only
Indole → N-Tosylindole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Indole | HCID 798 | — |
| Reactant | 4-Toluenesulfonyl chloride | HCID 7397 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Solvent | 1,2-Dimethoxyethane | HCID 8071 | — |
| Product | N-Tosylindole | HCID 10956616 | 89% |
Reaction Steps
1-(p-toluenesulphonyl)indole was prepared according to the procedure described in Y. Kikugawa Synthesis 1981, 460-461, by reaction of indole with p-toluenesulphonyl chloride in the presence of potassium hydroxide in dimethoxyethane at ambient temperature for 30 minutes. Yield: 89%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08343964B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-9598e6ab4c82426f8ff0125526ba3cf4 |
| Source note | uspto-grants-2013_01 |