HuagongsheHuagongshe Chemistry Print Report · For research reference only
Indole → 1-(dimethyl-t-butylsilyl)indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Indole | HCID 798 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | tert-Butyldimethylsilyl chloride | HCID 28928 | — |
| Reactant | HCID 178507088 | HCID 178507088 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-(dimethyl-t-butylsilyl)indole | HCID 10060091 | 79% |
Reaction Steps
1-(dimethyl-t-butylsilyl)indole is prepared by treatment of indole with sodium hydride in THF at temperature followed by the reaction of 1-sodioindole with dimethyl-t-butylsilyl chloride in THF according to the procedure described in D. Dhanak, C. B. Reese J. Chem. Soc., Perkin Trans. 1 1986, 2181-2186. The yield is 79%. The physical and spectral characteristics are described in this article.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08343964B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-6f1a8fdc0dc247f4abc79d549a30fd69 |
| Source note | uspto-grants-2013_01 |