反应详情

a mixture of benzyl 2-cyano-2-(2-nitro-4-methylphenyl)ethanoate (13 mmol), 5% palladium (0.84 g), water (4 mL) and ethanol (40 mL) is hydrogenated under 50 psi for 18 hours at 25° C. The catalyst is eliminated by filtration on celite and the solid is washed with ethanol. The filtrate obtained is evaporated under vacuum and the residue is purified by chromatography on silica gel (eluent: CH2Cl2/pentane, 2/1) in order to produce 6-methylindole with a yield of 74%.

1. filtrationThe catalyst is eliminated by filtration on celite
2. washthe solid is washed with ethanol
3. customThe filtrate obtained
4. customis evaporated under vacuum
5. customthe residue is purified by chromatography on silica gel (eluent: CH2Cl2/pentane, 2/1) in order