3,4-dihydro-2H-pyran → HCID 58292840, compound

Participants

Reaction Steps

A mixture of 2-bromo-4,6-dihydroxybenzaldehyde (4.34 g, 20.0 mmol) and PPTS (0.51 g, 2.0 mmol) in dichloromethane (100 mL) was added DHP (3.02 g, 36.0 mmol). The reaction mixture was stirred at room temperature overnight and concentrated in vacuo. The residue was purified by column chromatography (EtOAc/PE=1/15) on silica gel to give the title compound as a colorless oil. (4.52 g, Y: 75.1%).

Provenance & Evidence