Benzyl Bromide → HCID 58292748, compound

Participants

Reaction Steps

To a mixture of 2-bromo-6-hydroxy-4-(tetrahydro-2H-pyran-2-yloxy)benzaldehyde (1.8 g, 6.0 mmol) and anhydrous K2CO3 (1.66 g, 12.0 mmol) in DMF (10 mL) was slowly added 1-(bromomethyl)benzene (1.22 g, 7.2 mmol) at 0° C. The reaction mixture was allowed to warm to room temperature and stirred for 2 h before quenched by water (15 mL). The resulting mixture was further stirred for 20 min and white precipitate was collected by filtration. The solid was washed with ether and dried under high vacuum to give the title compound as a white powder (3.9 g, yield: 83%).

Provenance & Evidence