2-Bromopropane → HCID 58292829, compound

Participants

Reaction Steps

To a mixture of ethyl 2-(1,4-dihydroxy-6-(tetrahydro-2H-pyran-2-yloxy)-1,3-dihydrobenzo[c][1,2]oxaborol-3-yl)acetate (320 mg, 0.95 mmol) and anhydrous K2CO3 (480 mg, 3.48 mmol) in DMF (10 mL) at 0° C. under N2 atmosphere was added 2-bromopropane (400 mg, 3.30 mmol). The reaction mixture was stirred at room temperature overnight and extracted with EtOAc (2×20 mL). The combined organic layers were dried over anhydrous Na2SO4 and concentrated in vacuo. The residue was purified by prep HPLC to give the title compound (110 mg. Yield: 30.6%)

Provenance & Evidence