Lithium Hydroxide → HCID 50923088, compound

Participants

Reaction Steps

The mixture of ethyl 2-(1-hydroxy-4-methyl-6-(2-(methylamino)-2-oxoethoxy)-1,3-dihydrobenzo[c][1,2]oxaborol-3-yl)acetate (321 mg, 1 mmol), LiOH (119.5 mg, 5 mmol) in THF/MeOH/H2O (5 ml/5 ml/10 ml) was stirred at room temperature for 4 hrs. The reaction mixture was quenched with 3N HCl. Filter the precipitate and washed with water. Dried to give desired product 150 mg as white powder. 1H NMR (400 MHz, DMSO-d6) δ 12.3 (s, 1H), 9.14 (s, 1H), 7.97 (s, 1H), 7.01 (s, 1H), 6.88 (s, 1H), 5.42 (d, J=9.6 Hz, 1H), 4.42 (s, 2H), 3.20 (dd, J=15.6, 2.4 Hz, 1H), 2.63 (d, J=3 Hz, 3H), 2.48 (s, 3H), 2.05 (dd, J=9.6, 15.6 Hz, 1H). MS (ESI) m/z=292 [M−H]−.

Provenance & Evidence