Hydrochloric Acid → tert-Butyl 2-(1,6-dihydroxy-4-methyl-1,3-dihydrobenzo[c][1,2]oxaborol-3-yl)acetate

Participants

Reaction Steps

To a solution of tert-butyl 2-(1-hydroxy-4-methyl-6-(tetrahydro-2H-pyran-2-yloxy)-1,3-dihydrobenzo[c][1,2]oxaborol-3-yl)acetate (2.2 g, 6.07 mmol) in 15 mL THF was added 2N HCl (6 mL) at 0° C. The mixture was stirred overnight at room temperature and concentrated in vacuo. The residue was purified by column to give the desired product (1.2 g, yield: 71%).

Provenance & Evidence