Hydrochloric Acid → HCID 58292703, compound

Participants

Reaction Steps

To a solution of {6-[3-(3-tert-butoxycarbonylamino-propoxy)-phenoxy]-1-hydroxy-4-methyl-1,3-dihydro-benzo[c][1,2]oxaborol-3-yl}-acetic acid ethyl ester (0.6 g, 1.2 mmol) in THF:H2O (1:1, 10 mL) at 0° C. was added a solution of LiOH (0.086 g, 3.6 mmol) in water (1 mL). The solution was allowed to warm to room temperature over 3 hours then acidified to pH 2 with 1N HCl at 0° C. and extracted with EtOAc (2×10 mL). The organic extracts were dried and concentrated in vacuo to give crude 6-[3-(3-tert-butoxycarbonylamino-propoxy)-phenoxy]-1-hydroxy-4-methyl-1,3-dihydro-benzo[c][1,2]oxaborol-3-yl}-acetic acid (0.5 g) which was used without further purification MS (ESI) m/z=470 [M−H]−.

Provenance & Evidence