Hydrochloric Acid → HCID 58292680, compound

Participants

Reaction Steps

To a solution of [1-hydroxy-4-methyl-6-(pyridin-2-yloxy)-1,3-dihydro-benzo[c][1,2]oxaborol-3-yl]-acetic acid ethyl ester (75 mg, 0.23 mmol) in THF (4 mL) was added LiOH (20 mg, 0.48 mmol) in water (2 mL). The mixture was stirred at room temperature for 5 h and acidified by 1N HCl to pH 3. The mixture was concentrated and purified by HPLC affording the title compound (52 mg, 75%) as a white solid. 1H NMR (DMSO) δ 9.26 (m, 1H), 8.19 (s, 1H), 7.89 (m, 1H), 7.24 (s, 1H), 7.17 (m, 1H), 7.08 (m, 1H), 7.05 (m, 1H), 5.55 (d, 1H), 3.13 (d, 1H), 2.31 (s, 3H), 2.13 (m, 1H). MS found: (M+H)+=300.10.

Provenance & Evidence