Hydrochloric Acid → HCID 67252926, compound

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A solution of {6-[2-(3-tert-butoxycarbonylamino-propylamino)-pyrimidin-4-yloxy]-1-hydroxy-4-methyl-1,3-dihydro-benzo[c][1,2]oxaborol-3-yl}-acetic acid (0.27 g, 0.57 mmol) in dioxane (7 mL) was treated with 4N HCl in dioxane (2 mL) at room temperature and stirred for 3 hours at room temperature. The precipitated solid was collected by vacuum filtration, dissolved in water and lyophilized to give {6-[2-(3-amino-propylamino)-pyrimidin-4-yloxy]-1-hydroxy-4-methyl-1,3-dihydro-benzo[c][1,2]oxaborol-3-yl}-acetic acid hydrochloride salt as a yellow solid (0.12 g, 56%). 1H NMR (400 MHz, DMSO-d6) δ 8.57 (br s, 1H), 8.37-8.10 (br m, 1H), 7.94 (br m, 3H), 7.50-7.25 (br m, 1H), 7.20-7.05 (br m, 1H), 6.47 (br s, 1H), 5.54 (d, J=9.38 Hz, 1H), 3.36 (br m, 1H), 3.20-3.00 (m, 2H), 2.80 ((m, 1H), 2.67 (m, 1H), 2.33 (s, 3H), 2.20-2.07 (m, 1H), 1.95-1.60 (m, 2H). MS (ESI) m/z: 371 [M−1].

Provenance & Evidence