Cesium carbonate → HCID 58292620, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of ethyl-2-(4-fluoro-1,6-dihydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-3-yl)acetate (0.25 g, 1.0 mmol), cesium carbonate (0.65 g, 2.0 mmol) and 2-chloropyrazine (0.17 g, 1.5 mmol) in DMF (3 mL) was heated to 90° C. for 3 hr. The reaction mixture was concentrated in vacuo and the residue was purified by column chromatography (EtOAc/PE=1/2) on silica gel to give the title compound as a light yellow solid (0.25 g, Yield: 76.7%). MS (ESI) m/z=333 [M+H]+.

Provenance & Evidence