Hydrochloric Acid → HCID 58292697, compound

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To a solution of [6-(3-cyano-pyrazin-2-yloxy)-1-hydroxy-4-methyl-1,3-dihydro-benzo[c][1,2]oxaborol-3-yl]-acetic acid ethyl ester (100 mg, 0.283 mmol) in THF (3 mL) was added NaOH (1N in H2O, 2.0 mL). The resulting solution was stirred at room temperature overnight. The mixture was diluted with H2O and acidified to pH 3 with 1N HCl at 0° C. The resulting mixture was extracted with ethyl acetate. The organic phase was separated, dried (Na2SO4), and concentrated. The crude mixture was purified by prep HPLC to give the title compound (150 mg, 82%) as a white solid. 1H NMR (CD3OD) δ 8.33 (d, 1H), 8.23 (d, 1H), 7.20 (d, 1H), 7.08 (d, 1H), 5.64 (dd, 1H), 3.15 (dd, 1H), 2.34 (s, 3H), 2.26 (dd, 1H). MS found: (M+H)+: 345.

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