HCID 67253812, compound → HCID 58292552, compound

Participants

Reaction Steps

To a mixture of [6-(5-cyano-pyrazin-2-yloxy)-1-hydroxy-4-methyl-1,3-dihydro-benzo[c][1,2]oxaborol-3-yl]-acetic acid ethyl ester (1.63 g) and Pd/C (250 mg) in methanol (80 mL) was degassed 3 times and the suspension was charged with H2 balloon at room temperature overnight. The reaction mixture was filtered through a pad of Celite and the filtrate was concentrated to dryness, affording the title compound (1.45 g). 1H NMR (300 MHz, CD3OD) δ 8.49 (s, 1H), 8.44 (s, 1H), 8.21 (s, 1H), 7.21 (s, 1H), 7.10 (s, 1H), 5.70-5.66 (m, 1H), 4.29 (s, 2H), 4.19 (q, 2H), 3.22-3.16 (m, 1H), 2.54-2.46 (m, 1H), 2.40 (s, 3H), 1.24 (t, 3H). MS found: (M+H)+=358.2.

Provenance & Evidence