Lithium Hydroxide → HCID 58292552, compound

Participants

Reaction Steps

A solution of [6-(5-aminomethyl-pyrazin-2-yloxy)-1-hydroxy-4-methyl-1,3-dihydro-benzo[c][1,2]oxaborol-3-yl]-acetic acid ethyl ester (700 mg, 2.24 mmol) in THF (16 mL) was treated with LiOH (470 mg, 11.2 mmol) in water (8 mL) at room temperature for 2 h. The reaction was concentrated to dryness. The residue was diluted with water and adjusted to pH 3. The mixture was purified by preparative HPLC to give the title compound (250 mg). 1H NMR (300 MHz, CD3OD) δ 8.48 (s, 1H), 8.35 (s, 1H), 8.21 (s, 1H), 7.18 (s, 1H), 7.07 (s, 1H), 5.70-5.63 (m, 1H), 4.29 (s, 2H), 3.18-3.12 (m, 1H), 2.40 (s, 3H), 2.36-2.28 (m, 1H). MS found: (M+H)+=330.1.

Provenance & Evidence