Triethylamine → HCID 178470805, compound

Participants

Reaction Steps

[6-(5-Cyano-pyrazin-2-yloxy)-1-hydroxy-4-methyl-1,3-dihydro-benzo[c][1,2]oxaborol-3-yl]-acetic acid ethyl ester (200 mg, 0.57 mmol) and hydroxylamine hydrochloride (99 mg, 1.4 mmol) were mixed in methanol (5.4 mL). To this was added triethylamine (0.28 mL, 2 mmol). The reaction was stirred at room temperature overnight. The solvent was removed. The residue was dissolved in dichloromethane and washed with water. The organic layer was separated and the solvent was removed to give a residue. The residue was dried under high vacuum to give the title compound (174 mg, 79%) as a white solid. MS found (electrospray): (M+H)+=387.1.

Provenance & Evidence