Hydrochloric Acid → HCID 58292698, compound

Participants

Reaction Steps

[6-(5-tert-Butoxycarbonylamino-pyrazin-2-yloxy)-1-hydroxy-4-methyl-1,3-dihydro-benzo[c][1,2]oxaborol-3-yl]-acetic acid (70 mg, 0.17 mmol) was treated with 4M HCl in dioxane (1 mL, 4 mmol) and stirred at room temperature for 3 h. The reaction mixture was concentrated under vacuum and purified by HPLC affording the title compound (40 mg, 75%) as a white solid. 1H NMR (CD3OD) δ 7.79 (s, 1H), 7.64 (s, 1H), 7.02 (d, 1H), 6.98 (d, 1H), 5.65 (dd, 1H), 3.35 (m, 1H), 3.20 (dd, 1H), 2.36 (s, 3H). MS found: (M+H)+: 316.05.

Provenance & Evidence