Isopropyl iodide → HCID 58292706, compound

Participants

Reaction Steps

To a mixture of ethyl 2-(1,4-dihydroxy-6-(pyrazin-2-yloxy)-1,3-dihydrobenzo[c][1,2]oxa-borol-3-yl)acetate (100 mg, 0.30 mmol) and 2-iodopropane (154 mg, 0.91 mmol) in DMF (5 mL) was added 60% NaH (4.85 mg, 1.21 mmol) at 0° C. The reaction mixture was stirred at room temperature for 1 h and quenched by slow addition of water (3 mL). The resulting mixture was acidified with 1 N HCl to pH=4 and extracted with EtOAc (2×15 mL). The combined organic layers were washed with water (10 mL) and brine (10 mL), dried over anhydrous Na2SO4 and concentrated in vacuo to give the title compound as a yellow oil (96 mg, yield: 86%).

Provenance & Evidence