Hydrochloric Acid → HCID 58292669, compound

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Reaction Steps

A solution of [4-(2-tert-butoxycarbonylamino-ethoxy)-1-hydroxy-6-(pyrazin-2-yloxy)-1,3-dihydro-benzo[c][1,2]oxaborol-3-yl]-acetic acid ethyl ester (47 mg) in acetic acid (4 mL) was treated with 1N HCl (1 mL) at 100° C. 2 h. The reaction was concentrated to dryness. The residue was purified by preparative HPLC to give the title compound (22 mg) as a white solid. 1H NMR (300 MHz, CD3OD) δ 8.47 (s, 1H), 8.34-8.33 (m, 1H), 8.17-8.15 (m, 1H), 7.08 (d, J=1.8 Hz, 1H), 7.04 (d, J=1.8 Hz, 1H), 5.76-5.72 (m, 1H), 4.35-4.32 (m, 2H), 3.47-3.44 (m, 2H), 3.31-3.25 (m, 1H), 2.57-2.49 (m, 1H). MS calcd for (C15H16BN3O6+H)+: 346.2. MS found: (M+H)+=346.2.

Provenance & Evidence