Hydrochloric Acid → HCID 58292645, compound

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Reaction Steps

A solution of [4-(3-tert-butoxycarbonylamino-propoxy)-1-hydroxy-6-(pyrazin-2-yloxy)-1,3-dihydro-benzo[c][1,2]oxaborol-3-yl]-acetic acid ethyl ester (81 mg) in acetic acid (4 mL) was treated with 1N HCl (1 mL) at 100° C. for 2 h. The reaction was concentrated to dryness. The residue was purified by preparative HPLC to give the title compound (32 mg) as a white solid. 1H NMR (300 MHz, CD3OD) δ 8.42 (s, 1H), 8.31-8.30 (m, 1H), 8.17-8.15 (m, 1H), 6.98 (d, J=1.5 Hz, 1H), 6.90 (d, J=1.5 Hz, 1H), 5.66-5.62 (m, 1H), 4.16 (t, 2H), 3.19 (t, 2H), 3.17-3.09 (m, 1H), 2.47-2.39 (m, 1H), 2.23-2.21 (m, 2H). MS calcd for (C16H18BN3O6+H)+:360.2. MS found: (M+H)+=360.2.

Provenance & Evidence