HCID 58292807, compound → HCID 58292578, compound

Participants

Reaction Steps

A solution of [4-benzyloxy-1-hydroxy-6-(pyrazin-2-yloxy)-1,3-dihydro-benzo[c][1,2]oxaborol-3-yl]-acetic acid ethyl ester (410 mg, 0.976 mmol) in THF/EtOH (20 mL, 1:1) was degassed 3 times and Pd/C (40 mg) was added. The suspension was degassed 3 times and charged with H2 at room temperature overnight. The reaction was filtered through a pad of Celite and the filtrate was concentrated to dryness. The residue was purified by preparative HPLC to give the title compound (200 mg, 62%). MS calcd for (C15H15BN2O6+H)+: 331.1. MS found: (M+H)+=331.1.

Provenance & Evidence