Potassium Carbonate → HCID 58292875, compound

Participants

Reaction Steps

A solution of [1,4-dihydroxy-6-(pyrazin-2-yloxy)-1,3-dihydro-benzo[c][1,2]oxaborol-3-yl]-acetic acid ethyl ester (100 mg, 0.303 mmol) in DMF (10 mL) was treated with (3-bromo-propyl)-carbamic acid tert-butyl ester (100 mg, 0.454 mmol) and potassium carbonate (209 mg, 1.52 mmol) at 50° C. for 5 h. The reaction was concentrated to dryness. The residue was diluted with MeOH/H2O and the mixture was adjusted pH to 3. The solution was purified by preparative HPLC to afford the title compound as a white solid (88 mg, 60%). MS calcd for (C23H30BN3O8+H)+: 488.2. MS found: (M+H)+=488.2.

Provenance & Evidence