Acetic Anhydride → HCID 58292652, compound

Participants

Reaction Steps

To a solution of crude ethyl 2-(1-hydroxy-6-(5-(N-hydroxycarbamimidoyl)thiazol-2-yloxy)-4-methyl-1,3-dihydrobenzo[c][1,2]oxaborol-3-yl)acetate (6.2 g crude) in 30 ml of acetic acid was added 400 ul of acetic anhydride. After the mixture was stirred at room temperature for one and half hour, it was treated with palladium (10% wet on charcoal, 1.8 g) and then hydrogenation on Parr-shaker for five hours. The mixture was filtered through a Celite pad and the filtrate was concentrated and dried under hi-Vac to give the crude product. The crude was used in subsequent steps without further purification.

Provenance & Evidence