HCID 58292560, compound → HCID 58292614, compound

Participants

Reaction Steps

To a solution of [6-(3-chloro-[1,2,4]thiadiazol-5-yloxy)-1-hydroxy-4-methyl-1,3-dihydro-benzo[c][1,2]oxaborol-3-yl]-acetic acid ethyl ester (400 mg, 1.08 mmol) in MeOH (10 mL) was added Pd/C (300 mg, 75%). The resulting solution was degassed, and reacted under H2 (60 psi) for 2 days. The mixture was filtrated. The filtration was removed in vacuo and purified by column chromatography (silica, DCM/MeOH 4:1) affording the title compound (120 mg, 35%) as a white solid. MS found: (M+H)+: 335.

Provenance & Evidence