Diazomethane → HCID 25119717, compound

Participants

Reaction Steps

To a solution of (1R,2R)-2-{[3-({cyclopropyl[((3R,4S)-4-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}piperidin-3-yl)carbonyl]amino}methyl)-5-(3-methoxypropyl)phenoxy]methyl}cyclopropanecarboxylic acid (1 eq., neutral form) from Example 2 was added a solution of diazomethane in ether until a faint yellow color persisted. The solvent was evaporated by a stream of nitrogen gas. The residue was purified by flash column chromatography (SiO2, 10% MeOH in DCM plus 1% aqueous NH4OH) afford the title compound as a colorless oil.

Provenance & Evidence