Sodium Hydroxide → HCID 25119358, compound

Participants

Reaction Steps

To a solution of methyl 4-{[3-({cyclopropyl[((3R,4S)-4-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}piperidin-3-yl)carbonyl]amino}methyl)-5-(3-methoxypropyl)phenoxy]methyl}benzoate (1 eq.) from Example 18 in methanol (0.03) was added 1 N aqueous NaOH (2.2 eq.). The reaction was heated to reflux and stirred for 18 h. The volatiles were removed in vacuo and the resulting solid residue was triturated with ether. The resulting residue was then taken up in EtOAc and the insolubles were removed via filtration. To the filtrate was then slowly added ether to precipitate out the sodium salt of the title compound as a white solid.

Provenance & Evidence