Tert-Butyl-[5''-(3-methoxy-phenyl)-[2,2';4',3'']terpyridin-6'-yl]-amine → 5''-(3-Methoxy-phenyl)-[2,2';4',3'']terpyridin-6'-ylamine

Participants

Reaction Conditions

Reaction Steps

Tert-Butyl-[5″-(3-methoxy-phenyl)-[2,2′;4′,3″]terpyridin-6′-yl]-amine (1 eq, 0.073 mmol, 0.030 g) is dissolved in TFA (6 ml)/DCM (1 ml) and the reaction mixture is heated at 70° C. for 5 hours. The reaction mixture is cooled down and reduced in vacuo. The resulting residue is dissolved in MeOH and loaded onto a SCX-2 cartridge eluting with MeOH followed by 2M NH3 in MeOH. The methanolic ammonia fractions are combined, concentrated in vacuo and dried under vacuum to afford the title compound; [M+H]+ 355.

Provenance & Evidence