HCID 68734150, compound → HCID 68758474, compound

Participants

Reaction Steps

A solution of {(R)-1-[4-(6′-cyclopropylamino-[2,2′;4′,3″]terpyridin-5″-yl)-benzyl]-pyrrolidin-3-yl}-carbamic acid tert-butyl ester (step 1) (1 eq, 0.204 mmol, 115 mg) in DCM/TFA (1 ml of a 3:1 mixture) is stirred at room temperature for 30 mins. The solvent is reduced in vacuo and the residue is purified by preparative HPLC (C18, 0-100% acetonitrile in water—0.1% TFA). The appropriate fractions by HPLC are combined and concentrated in vacuo. The resulting residue is dissolved in MeOH and loaded onto a SCX-2 cartridge eluting with MeOH and 2M NH3 in MeOH. The methanolic ammonia fractions are combined, concentrated in vacuo and dried under vacuum to afford the title compound; [M+H]+ 463.

Provenance & Evidence