(3S)-(-)-3-(tert-Butoxycarbonylamino)pyrrolidine → HCID 68940194, compound

HRID 1798500Notes

Reaction equation

HRID 1798500 reaction equation
[NH2:1][C@@H:2]1[CH2:6][CH2:5][N:4]([CH2:7][C:8]2[CH:13]=[CH:12][C:11]([C:14]3[CH:15]=[C:16]([C:20]4[CH:25]=[C:24]([NH:26][CH:27]5[CH2:29][CH2:28]5)[N:23]=[C:22]([C:30]5[CH:35]=[CH:34][CH:33]=[CH:32][N:31]=5)[CH:21]=4)[CH:17]=[N:18][CH:19]=3)=[CH:10][CH:9]=2)[CH2:3]1.C(OC(=O)N[C@H]1CCNC1)(C)(C)C>>[NH2:1][C@H:2]1[CH2:6][CH2:5][N:4]([CH2:7][C:8]2[CH:9]=[CH:10][C:11]([C:14]3[CH:15]=[C:16]([C:20]4[CH:25]=[C:24]([NH:26][CH:27]5[CH2:28][CH2:29]5)[N:23]=[C:22]([C:30]5[CH:35]=[CH:34][CH:33]=[CH:32][N:31]=5)[CH:21]=4)[CH:17]=[N:18][CH:19]=3)=[CH:12][CH:13]=2)[CH2:3]1

Participants

3

Reactant 2

HCID 1514396(3S)-(-)-3-(tert-Butoxycarbonylamino)pyrrolidineHCID 68758474HCID 68758474, compound

Product 1

HCID 68940194HCID 68940194, compound

Procedure

This compound is prepared analogously to {5″-[4-((R)-3-Amino-pyrrolidin-1-ylmethyl)-phenyl]-[2,2′;4′,3″]terpyridin-6′-yl}-cyclopropyl-amine (Example 2.76) by replacing (R)-pyrrolidin-3-yl-carbamic acid tert-butyl ester with (S)-pyrrolidin-3-yl-carbamic acid tert-butyl ester. [M+H]+ 463.

Sources & evidence

ORD record
ord-11dabc7a40634f6eafb738fcf0241181
Source dataset
uspto-grants-2013_01
Patent number
US08343966B2

Reaction notes

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