Hydrochloric Acid → 1-(5''-Bromo-[2,2';4',3'']terpyridin-6'-yl)-1-methyl-ethylamine

Participants

Reaction Steps

N-[1-(5″-Bromo-[2,2′;4′,3″]terpyridin-6′-yl)-1-methyl-ethyl]-acetamide (Example 2.97; step1) (1 eq, 0.151 mmol, 62 mg) and SM HCl (20 eq, 3.01 mmol, 0.602 ml) are heated together at 100° C. overnight. The pH of the reaction mixture is adjusted to 8-9 by addition of sodium hydroxide (2M). The solution is dissolved in DCM and washed with water. The combined organic extracts are washed with brine, dried over MgSO4 and concentrated in vacuo to afford the title compound; [M+H]+ 369/371

Provenance & Evidence